Solid-phase analytical derivatization: enhancement of sensitivity and selectivity of analysis. |
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Authors: | J M Rosenfeld |
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Institution: | Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. |
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Abstract: | Analytical derivatizations enhance the sensitivity and selectivity of determinations for organic compounds. Classical techniques are often based on solution chemistry. Most modern sample preparation techniques, however, are based on solid-phase extractions. Solid-phase analytical derivatization bridges this gap and facilitates sample preparation by combining the isolation step with the derivatization. The solid-phase retains both reagents and derivatized analytes and often permits facile separation of excess reagent or selective elution of the desired products. The most recent solid-phase extraction techniques have been used in conjunction with analytical derivatization to automate the analysis. In this review, analytical derivatizations are presented as functional group analysis. |
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