| Synthesis of New Chrial Building Blocks for Novel Peptide Nucleic Acids |
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| 作者姓名： | WU Jie XU Xiao-Yu LIU Ke-Liang |
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| 作者单位： | BeijingInstituteofPharmacologyandToxicology,Beijing100850,China |
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| 摘 要： | N-Boc protected amino acids of analogues of peptide nucleic acid (PNA),which are a class of conformationally constrained building blocks based on 4-aminoproline backbone with chirality at 2-c and 4-c,have been synthesized.Those monomers can be used for the construction of novel peptide nucleic acid analogues.
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| 关 键 词： | 长链缩氨酸 手性化合物 核酸 合成 类似物 |
Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids |
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| WU,Jie XU,Xiao-Yu LIU,Ke-Liang.Synthesis of New Chrial Building Blocks for Novel Peptide Nucleic Acids[J].Chinese Journal of Chemistry,2003,21(5):566-573. |
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| Authors: | Wu Jie Xu Xiao‐Yu Liu Ke‐Liang |
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| Abstract: | N‐Boc protected amino acids of analogues of peptide nucleic add (PNA.), which are a class of conformationally constrained building blocks based on 4‐aminoproline backbone with chirality at 2‐C and 4‐C, have been synthesized. Those monomers can be used for the construction of novel peptide nucleic acid analogues. |
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| Keywords: | oligonucleotide peptide nucleic acids pyrrolidine synthesis |
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