Sonogashira reaction on pyridinium N-heteroarylaminides |
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| Authors: | Marta Có rdobaM. Luisa Izquierdo,Julio Alvarez-Builla |
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| Affiliation: | Departamento de Química Orgánica, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain |
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| Abstract: | The reactivity of N-(5-iodopyridin-2-yl)aminide in a copper-free Sonogashira cross-coupling process is reported. The reaction proceeds on using PdCl2(PPh3)2 and DABCO as the base under microwave irradiation in acetonitrile or water as solvents. The process can also be carried out by traditional heating in acetonitrile on using Pd(AcO)2/DABCO with Cs2CO3. |
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| Keywords: | Pyridinium N-aminides Sonogashira Microwaves DABCO |
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