4-烷氧/苄氧基苯基四唑和1,3,4-噁二唑类化合物的合成及除草活性

以4-氰基苯酚为起始原料,在4-烷氧基/苄氧基苯甲脒结构基础上,设计合成了5个4-烷氧基/苄氧基苯基四唑及17个新型2-取代-5-(4-烷氧基/苄氧基)苯基噁二唑类化合物,通过元素分析、1H NMR和MS对所合成的新化合物进行了结构表征.初步除草活性测试结果表明,部分化合物对双子叶油菜和单子叶稗草表现出较好的生长抑制活性.

Synthesis and Herbicidal Activities of 4-Alkoxy/benzyloxyphenyltetrazoles and 1,3,4-Oxadiazoles

Tetrazoles and 1,3,4-oxadiazoles are important heterocyclic compounds with a wide range of pharmaceutical and biological activity.Their syntheses and herbicidal activity have been of interest for a long time.In our previous research,a series of 4-alkoxy(benzyloxy)benzamidines were synthsized and showed a favourable herbicidal activity and KARI inhibitory activity.For searching potent herbicidal activity compounds,in this paper,five 4-alkoxy/benzyloxyphenyltetrazoles and seventeen new 2-substituted-5-(4-alkoxy/benzyloxy)phenyloxadiazoles were designed on the basis of the structure of 4-alkoxy(benzyloxy)benzamidine and synthesized via 4-cyanophenol as the starting material.All synthesized novel compounds were confirmed by elemental analysis,1H NMR and MS.The preliminary herbicidal assay indicates that some of them displayed a good herbicidal activity on di-cotyledonous rape(Brassica campestris)and mono-cotyledonous barnygrass(Echinochloa crusgalli).