Sorption and Swelling of Poly(D,L-lactic acid) and Poly(lactic-co-glycolic acid) in Supercritical CO2 |
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| Authors: | Ronny Pini Giuseppe Storti Marco Mazzotti Hongyun Tai Kevin M. Shakesheff Steven M. Howdle |
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| Affiliation: | 1. Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, 8092 Zurich, Switzerland Fax: (+41) 44 632 11 41;2. Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland;3. School of Chemistry, University of Nottingham, Nottingham, United Kingdom;4. School of Pharmacy, University of Nottingham, Nottingham, United Kingdom |
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| Abstract: | Summary: The equilibrium sorption and swelling behavior in supercritical CO2 of poly(D,L-lactic acid) and poly(lactic-co-glycolic acid) has been studied at a temperature of 35 °C and at pressures up to 200 bar. Sorption was measured through a gravimetric technique and swelling by visualization. From these data, the behavior of the different polymers can be compared. In terms of partial molar volume of CO2 in the polymer matrix, all the polymers exhibit a behavior typical of rubbery systems. The experimental results have been modeled using the Sanchez-Lacombe equation of state, which is able to represent the actual behavior of the polymer-CO2 systems with reasonable accuracy. |
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| Keywords: | biodegradable PLA PLGA sorption and swelling tissue engineering |
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