Polyester-based Copolymers for Biomaterials Fabrication |
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| Authors: | Neli Koseva Piotr Kurcok Grazyna Adamus Kolio Troev Marek Kowalczuk |
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| Institution: | 1. Polish Academy of Sciences, Centre of Polymer Chemistry, 41- 800 Zabrze, Poland;2. Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Bl. 103A, 1113 Sofia, Bulgaria |
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| Abstract: | Summary: Results on synthesis of poly(3-hydroxybutyrate)s possessing one or two hydroxyl groups at one terminus of the chain and carboxylic group at the other chain end are reported. These polymers were further functionalised via transesterification with dimethyl H-phosphonate thus incorporating a reactive/biodegradable center in the polyester backbone. Block/star-like copolymers composed of hydrophilic PEG and hydrophobic poly(3-hydroxybutyrate) segments linked by phosphoester moiety were also obtained. Chemical structure and composition of the reaction products were analysed applying different spectroscopic techniques (1H, and 31P NMR, IR and ESI-MS) and size exclusion chromatography was applied to describe molecular weight averages and distribution. |
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| Keywords: | biodegradable functionalization of polymers phosphoesters poly(3-hydroxybutyrate) |
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