Collagen-Derived Biomaterials in Bone and Cartilage Repair |
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Authors: | Ming H Zheng K Hinterkeuser K Solomon V Kunert N J Pavlos J Xu |
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Institution: | Department of Orthopaedic Surgery, School of Surgery & Pathology, University of Western Australia, Nedlands, 6009, Perth, Australia |
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Abstract: | Summary: We have analyzed a number of collagen-derived biomaterials for the matrix- induced and assisted bone and cartilage tissue regeneration. These include the Small intestine submuosa (SIS) Restor ™, ACI-Maix collagen membrane, Chondro- Gide collagen membrane, Permacol collagen Ossix and lycoll collagen membrane and five types of collagen-based marine sponge skeletons. Certain characteristics of different scaffold materials with comparable chemical composition may vary significantly. This variation may have a relevant impact on the suitability of the scaffolds for bone and cartilage regeneration. It suggests that the ACI-Maix® membrane is the best available collagen-derived material for an MACI®/MACT® application. In addition, the study of marine sponge indicates that the collagenous fibre skeleton of marine sponges provides a suitable bioscaffold for bone regeneration, as it supports the adhesion, migration and proliferation of osteoblasts in vitro. |
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Keywords: | biomaterials collagen membrane cell therapy MACI marine sponge |
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