Intramolecular azide-alkyne cycloaddition for the fast assembly of structurally diverse, tricyclic 1,2,3-triazoles |
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| Authors: | Oliva Ana I Christmann Ute Font Daniel Cuevas Félix Ballester Pablo Buschmann Helmut Torrens Antoni Yenes Susana Pericàs Miquel A |
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| Institution: | Institute of Chemical Research of Catalonia (ICIQ), Avenida Pa?sos Catalans 16, Tarragona, Spain. |
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| Abstract: | The synthesis of novel tricyclic 1,2,3-triazoles starting from cyclic epoxides via the sequential azidolysis, propargylation and 1,3-dipolar cycloaddition is described. Derivatization by N-arylation reaction and the synthesis of enantiomerically pure compounds is also reported. Some of these compounds exhibit significant affinity for the sigma-1 receptor. |
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