LC-NMR coupling technology: recent advancements and applications in natural products analysis |
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Authors: | Exarchou Vassiliki Krucker Manfred van Beek Teris A Vervoort Jacques Gerothanassis Ioannis P Albert Klaus |
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Affiliation: | NMR Center, Department of Chemistry, University of Ioannina, Greece. vexarc@cc.uoi.gr |
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Abstract: | An overview of recent advances in nuclear magnetic resonance (NMR) coupled with separation technologies and their application in natural product analysis is given and discussed. The different modes of LC-NMR operation are described, as well as how technical improvements assist in establishing LC-NMR as an important tool in the analysis of plant-derived compounds. On-flow, stopped-flow and loop-storage procedures are mentioned, together with the new LC-SPE-NMR configuration. The implementation of mass spectrometry in LC-NMR is also useful on account of the molecular weight and fragmentation information that it provides, especially when new plant species are studied. Cryogenic technology and capillary LC-NMR are the other important recent developments. Since the plant kingdom is endless in producing potential drug candidates, development and optimization of LC-NMR techniques convert the study of natural products to a less-time-consuming task, speeding up identification. |
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