Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides |
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| Authors: | Kimura Takumi Kawai Kiyohiko Majima Tetsuro |
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| Institution: | Institute of Scientific and Industrial Research (SANKEN), Osaka University Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan. |
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| Abstract: | The environment-sensitive fluorophore dan (6-dimethylamino-2-acyl-naphthalene)- modified dC or dG bases were introduced into the Z-DNA forming sequence. It was demonstrated that both grooves of Z-DNA are more hydrated than those of B-DNA. Dan will be useful for probing the microenvironments in the grooves among the DNA polymorphs. |
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