Asymmetric Michael additions of aldehydes to maleimides using a recyclable fluorous thiourea organocatalyst |
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Authors: | Tsuyoshi Miura Shohei NishidaAkira Masuda Norihiro TadaAkichika Itoh |
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Affiliation: | Gifu Pharmaceutical University, 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan |
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Abstract: | Fluorous thiourea organocatalyst 3 promotes the Michael reaction of aldehydes with maleimides to afford the corresponding adducts in high yields with up to 99% ee. Fluorous organocatalyst 3 can be easily recovered as an insoluble precipitate from the reaction mixture by simple filtration and can be reused without significant loss of catalytic activity. |
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Keywords: | Fluorous Organocatalyst Michael Maleimide Thiourea |
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