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A convenient synthesis of 1,2,4-trisubstituted azetidines by reductive cyclization of aza-Michael adducts of chalcones |
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| Authors: | Lal Dhar S Yadav Chhama Awasthi Vijai K Rai Ankita Rai |
| Institution: | Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211 002, India |
| Abstract: | Aza-Michael adducts of chalcones and diethyl N-arylphosphoramidates undergo reductive cyclization with sodium borohydride followed by sodium hydride to afford 1,2,4-trisubstituted azetidines diastereoselectively in a one-pot procedure and excellent yields. |
| Keywords: | Azetidines Michael addition Phosphoramidates Chalcones Reduction Cyclization reactions |
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