A short, practical synthesis of the ant venom alkaloid, three (3R,5S,8aS)-3-alkyl-5-methylindolizidines |
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Authors: | Hiroki Takahata Hiroshi Bandoh Takefumi Momose |
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Institution: | Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-01, Japan |
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Abstract: | A short, practical and diastereoselective method for preparing the ant venom alkaloid, three (3R,5S,8aS)-3-alkyl-5-methylindolizidines (1–3), has been developed. The stereoselective intramolecular amidomercuration of the N-alkenylurethane 4 followed by oxidative demercuration provides the piperidine alcohol cis-6 as a major product. Thereafter, oxidation of cis-6 followed by the Horner-Emmons elongation of the ring appendages affords the enones 8, 10, and 11, which are stereoselectively converted into 1, 2, and 3, respectively, by catalytic hydrogenation. |
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