Parallel solution-phase synthesis of acrylonitrile scaffolds carrying L-alpha-amino acidic or D-glycosyl residues |
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Authors: | Fioravanti Stefania Pellacani Lucio Tardella Paolo A Morreale Alberto Del Signore Giuseppe |
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Institution: | Dipartimento di Chimica, Università degli Studi La Sapienza, P.le Aldo Moro 2, I-00185 Roma, Italy. |
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Abstract: | A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles. |
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