A new iridoid glycoside from the roots of Dipsacus asper |
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Authors: | Ji De Zhang Chunfeng Li Jingzhi Yang Haowei Shen Jingyang Yang Zhonglin |
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Institution: | State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China. yzl1950@tom.com. |
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Abstract: | A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4',4'-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ????? induced cell death in PC12 cells. |
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