Determination of Zy 17617B in plasma by solid-phase extraction and liquid chromatography with automated pre-column exchange. |
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| Authors: | D Chollet M Salanon |
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| Institution: | Zyma S.A., Department of Toxicology and Pharmacokinetics, Nyon, Switzerland. |
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| Abstract: | An automated chromatographic system, combining solid-phase extraction and automated pre-column exchange, is described for the routine determination of Zy 17617B at the pmol/ml level in human plasma. The sample extraction and elution onto the analytical column were performed automatically and concomitantly using a conventional liquid chromatographic apparatus equipped with a Merck OSP-2 on-line sample preparator. Validation data demonstrate the reliability of the method. |
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