HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants |
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| Authors: | E De Lorenzi G Massolini M Macchia G Caccialanza |
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| Institution: | (1) Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy;(2) Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56100 Pisa, Italy |
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| Abstract: | Summary A reversed-phase HPLC method has been developed for the urinary determination of mutagenic 2,4- and 2,6-toluendiamines. These
amines are degradation products of polyurethane, a material used to cover textured silicone breast implants. FMOC-Cl was used
as fluorescent derivatising agent in order to obtain a limit of detection of 15 ng/ml in urine. Pre-treatment of urine samples
was by liquid/liquid extraction and urine specimens of patients after surgury were analysed. |
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| Keywords: | Column liquid chromatography Polyurethane degradation products 2 4- and 2 6-toluendiamine Urine analysis Breast implants |
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