Structure,biological and electrochemical studies of transition metal complexes from N,S,N′ donor ligand 8-(2-pyridinylmethylthio)quinoline |
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| Authors: | Jing-An Zhang Mei Pan Rui Yang Zhi-Gang She Wolfgang Kaim Zhi-Jin Fan Cheng-Yong Su |
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| Institution: | 1. MOE Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China;2. Institut für Anorganische Chemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany;3. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China |
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| Abstract: | The semirigid tridentate 8-(2-pyridinylmethylthio)quinoline ligand (Q1) is shown to form the structurally characterized transition metal complexes Cu(Q1)Cl2] (1), Co(Q1)(NO3)2] (2), Cd(Q1)(NO3)2] (3), Cd(Q1)I2] (4). Cu(Q1)2](BF4)2·(H2O)2 (5), Cu(Q1)2](ClO4)2·(CH3COCH3)2 (6), Zn(Q1)2](ClO4)2(H2O)2 (7), Cd2(Q1)2Br4] (8), Ag2(Q1)2(ClO4)2] (9), and Ag2(Q1)2(NO3)2] (10). Four types of structures have been observed: ML-type in complexes 1–4, in which the anions Cl−, NO3− or I− also participate in the coordination; ML2− type in complexes 5–7 without direct coordination of the anions BF4− or ClO4− and with more (Cu2+) or less (Zn2+) distorted bis-fac coordinated Q1; M2L2-type in complex 8, in which two Br− ions act as bridges between two metal ions; and M2(μ-L)2-type in complexes 9 and 10, in which the ligand bridges two anion binding and Ag–Ag bonded ions. Depending on electron configuration and size, different coordination patterns are observed with the bonds from the metal ions to Npyridyl longer or shorter than those to Nquinoline. Typically Q1 acts as a facially coordinating tridentate chelate ligand except for the compounds 9 and 10 with low-coordinate silver(I). Except for 6 and 8, the complexes exhibit distinct constraining effects against both G(+) and G(-) bacteria. Complexes 1, 3, 4, 5, 7 have considerable antifungal activities and complexes 1, 5, 7, and 10 show selective effects to restrain certain botanic bacteria. Electrochemical studies show quasi-reversible reduction behavior for the copper(II) complexes 1, 5 and 6. |
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| Keywords: | Quinoline Chelate ligand Transition metal complexes Bioactivity Thioether ligand |
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