Synthesis,spectral characterization,electrochemical properties and antimicrobial screening of sulfur containing acylferrocenes |
| |
| Authors: | Danijela Ilić Ivan Damljanović Dragana Stevanović Mirjana Vukićević Niko Radulović Volker Kahlenberg Gerhard Laus Rastko D Vukićević |
| |
| Institution: | 1. Technical Faculty Kosovska Mitrovica, University of Priština, Kneza Miloša 7, 38220 Kosovska Mitrovica, Serbia;2. Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovi?a 12, 34000 Kragujevac, Serbia;3. Department of Pharmacy, Faculty of Medicine, University of Kragujevac, S. Markovi?a 65, 34000 Kragujevac, Serbia;4. Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia;5. Institute of Mineralogy and Petrography, University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria;6. Institute of Inorganic Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria |
| |
| Abstract: | Several known and eight new sulfur containing acylferrocenes of the general formula FcCO(CH2)nSR (where Fc = ferrocenyl, n = 1 or 2 and R = alkyl, 4-bromobenzyl or 2,6-dichlorobenzyl group) were synthesized in order to test their in vitro antimicrobial activity against 11 bacterial and three fungal/yeast strains. It has been shown that only four of the 14 ketones are completely inactive at the tested dose, while the activities of the other ones were noteworthy. All new compounds were well characterized by IR and NMR spectral data, and their electrochemical properties were investigated by cyclic voltammetry. The X-ray crystal structures of two representative ketones are also presented. |
| |
| Keywords: | Ferrocene Friedel-Crafts acylation S-Alkylthioglycolic acids 2-Alkylthiopropanoic acids Cyclic voltammetry Antimicrobial activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
