Rhenium(I) and technetium(I) fac-M(NSO)(CO)3 (M = Re,Tc) tricarbonyl complexes,with a tridentate NSO bifunctional agent: Synthesis,structural characterization,and radiochemistry |
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| Authors: | Dionysia Papagiannopoulou George Makris Charalambos Tsoukalas Catherine P. Raptopoulou Aris Terzis Maria Pelecanou Ioannis Pirmettis Minas S. Papadopoulos |
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| Affiliation: | 1. Department of Medicinal Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece;2. Institute of Radioisotopes–Radiodiagnostic Products, National Centre for Scientific Research “Demokritos”, 15310 Athens, Greece;3. Institute of Materials Science, National Centre for Scientific Research “Demokritos”, 15310 Athens, Greece;4. Institute of Biology, National Centre for Scientific Research “Demokritos”, 15310 Athens, Greece |
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| Abstract: | The synthesis and structural characterization of the neutral rhenium complex fac-[Re(NSO)(CO)3], Re-1, where (NSO) is a tridentate bifunctional chelating agent, 3-(carboxymethylthio)-3-(1H-imidazol-4-yl)propanoic acid (1), is presented. The complex crystallized from methanol–water and its structure was assigned by IR and 1H, 13C NMR spectroscopies and X-ray crystallography. Furthermore, the analogous technetium complex fac-[99mTc(NSO)(CO)3], 99mTc-1, was synthesized in high yield by reacting ligand 1 with the fac-[99mTc(OH2)3(CO)3]+ precursor for 30 min at 85 °C. The tracer complex was found to be more than 95% stable in the L-histidine challenge experiment. Our data indicate that the bifunctional NSO chelating agent 1 can be successfully applied for the development of potential 99mTc-radiopharmaceuticals. |
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| Keywords: | Rhenium Technetium Tricarbonyl complexes Bifunctional |
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