A new synthesis of 2-fluoro-1-naphthols |
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| Authors: | Xiaohong Cai |
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| Affiliation: | Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville FL 32611-7200, USA |
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| Abstract: | A general synthesis of 2-fluoro-1-naphthols in two steps from 1-indanones is reported. The 1-indanones are first converted to difluoromethyl 2-fluoro-1-napthyl ethers by reaction with difluorocarbene source, trimethylsilyl 2-fluorosulfonyl-2,2-difluoroacetate (TFDA). These ethers are then converted in high yield to the respective naphthols by heating with a mixture of acetic acid and 48% HBr. |
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| Keywords: | Difluorocarbene Indanone Fluoroaromatics |
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