Microwave-assisted rapid electrophilic fluorination of 1,3-dicarbonyl derivatives with Selectfluor |
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| Authors: | Ji-Chang Xiao |
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| Affiliation: | Department of Chemistry, University of Idaho, ID 83844-2343, USA |
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| Abstract: | A microwave-assisted fluorination method for 1,3-dicarbonyl compounds using Selectfluor® has been developed. 2-Monofluorinated products can be obtained in high yield in neutral reaction conditions with addition of 1 eq. of Selectfluor®. Treatment of 1,3-dicarbonyls with 3 eq. of Selectfluor® in the presence of tetrabutylammonium hydroxide (TBAH) as the base results in the formation of 2,2-difluorinated derivatives only. |
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| Keywords: | Microwave Electrophilic fluorination Selectfluor 1,3-Dicarbonyl compounds |
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