Recycling of fluorinated axially dissymmetric ligand with fluorous solvent |
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Authors: | Masaaki Omote |
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Institution: | Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata 573-0101, Japan |
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Abstract: | Axially dissymmetric ligand, (Ra)-2,2′-bis(R)-1-hydroxy-1H-perfluorooctyl]-biphenyl (1), showing a high asymmetric induction, was found to be recovered quantitatively with a fluorous solvent from the reaction mixture owing to its high fluorine content. The recovered ligand 1 was pure enough to be reused without purification. The efficiency of 1 as the chiral ligand was not reduced at all even after seven times recycling. |
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Keywords: | Fluorine Chiral Axial dissymmetry Recycling Ligand Fluorous solvent |
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