Nucleophilic trifluoromethylation of RF-containing 4-quinolones, 8-aza- and 1-thiochromones with (trifluoromethyl)trimethylsilane |
| |
Authors: | Vyacheslav Ya Sosnovskikh Boris I Usachev Gerd-Volker Röschenthaler |
| |
Institution: | a Department of Chemistry, Ural State University, Lenina 51, 620083 Ekaterinburg, Russian Federation b Institute of Inorganic & Physical Chemistry, University of Bremen, Leobener Strasse, 28334 Bremen, Germany |
| |
Abstract: | Reactions of N-substituted 2-polyfluoroalkyl-4-quinolones and 8-aza-5,7-dimethyl-2-polyfluoroalkylchromones with (trifluoromethyl)trimethylsilane proceed mainly as a 1,4-nucleophilic trifluoromethylation to give N-substituted 2,2-bis(polyfluoroalkyl)-2,3-dihydroquinolin-4(1H)-ones and 5,7-dimethyl-2,2-bis(polyfluoroalkyl)-2,3-dihydro-4H-pyrano2,3-b]pyridin-4-ones after acid hydrolysis. Similar reaction with 2-trifluoromethyl-4H-thiochromen-4-one proceeds as a 1,2-addition to give 2,4-bis(trifluoromethyl)-4H-thiochromen-4-yl trimethylsilyl ether. |
| |
Keywords: | RF-containing 4-quinolones 8-Aza- and 1-thiochromones Nucleophilic 1 4- and 1 2-trifluoromethylation (Trifluoromethyl)trimethylsilane |
本文献已被 ScienceDirect 等数据库收录! |
|