An efficient stereoselective synthesis of difluoromethylated alkenes in a microreactor |
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| Authors: | Tomoya Kitazume Kouichi Kawai Takashi Nihei Noriaki Miyake |
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| Institution: | Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku Yokohama 226-8501, Japan |
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| Abstract: | Synthetic utility of microreactors and highly stereoselective isomerization (>99:<1) of terminal difluoromethylated alkenes to (E)-difluoromethylated alkenes with TBAF in DMF, are described. |
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| Keywords: | Difluoromethylated alkene E-selective Microreactor |
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