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The effect of fluoromethyl groups on the diastereoselectivity in the electrophilic alkylation |
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| Authors: | Kenji Tamura Tomoya Kitazume Toshio Kubota |
| Affiliation: | a Graduate School of Bioscience and Bioengineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan b Department of Applied Chemistry, Tokyo University of Agriculture and Technology, 2-24-16 Naka-machi, Koganei, Tokyo 184-8588, Japan c Department of Materials Science, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibariki 316-8511, Japan |
| Abstract: | The effect of fluoromethyl groups on the diastereoselectivity in the electrophilic alkylation is described. In particular, the electrophilic alkylation of enolates with a trifluoromethyl group was proceeded with highly diastereofacial selectivity based on the steric and/or electrostatic effect of substituent with strong electron withdrawing. |
| Keywords: | Diastereoselectivity Electrophilic alkylation |
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