An efficient three-component synthesis of highly functionalized tetrahydroacenaphtho[1,2-b]indolone derivatives catalyzed by L-proline |
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| Authors: | Juan-Juan Zhang Xian Feng Xue-Cheng Liu Zhi-Bin Huang Da-Qing Shi |
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| Affiliation: | 1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People’s Republic of China
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| Abstract: | An efficient and diastereoselective synthetic procedure for highly functionalized tetrahydroacenaphtho[1,2- (b) ]indolone derivatives was successfully developed by the three-component reaction of acenaphthequinone, enaminones, and barbituric acid in the presence of a catalytic amount of L-proline. This method has the advantages of convenient operation, excellent yields, mild reaction conditions, and environmental friendliness. |
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