An accurately-constructed structural model for an active site of Fe-containing superoxide dismutases (Fe-SODs) |
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| Authors: | Yamaguchi Syuhei Kumagai Akinori Funahashi Yasuhiro Jitsukawa Koichiro Masuda Hideki |
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| Institution: | Department of Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan. |
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| Abstract: | A novel structural model, Fe(bpga)(N(3))(OCH(3))] (1) (BPGA: bis(6-pivalamido-2-pyridylmethyl)(carboxy-methyl)amine), for an active site of Fe-containing SOD enzyme with N(3)(-) has been accurately designed and prepared, which has been characterized by X-ray structure analysis and UV-vis, ESR, and IR spectroscopies. Reaction of 1 with acid/base in methanol has shown that the superoxide-accessible site is the N(3)(-)-coordination site in the equatorial plane. |
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