新型多取代硫代半卡巴腙类配体的合成与结构表征

为发展金属离子配体，设计合成了一系列新型多取代氨基硫脲。烯丙基异硫氰酸酯与水合肼溶液反应，制得4-烯丙基氨基硫脲(1)。1分别与联乙酰(2,3-丁二酮)、水合茚三酮、乙二醛反应，合成出联乙酰双缩(4-烯丙基氨基硫脲)(2)、茚三酮-1,3-二缩(4-烯丙基氨基硫脲)(5)、乙二醛二缩(4-烯丙基氨基硫脲)(6)。联乙酰和氨基硫脲反应制备出联乙酰双缩氨基硫脲(3)，环己酮与1在无水乙醇中回流反应合成出环己酮缩(4-烯丙基氨基硫脲)(4)。缩合反应操作简便，条件温和，反应时间只需0.5～2h，产物收率达到70%～87%。这些化合物均未见报道，其结构通过元素分析，IR、^1HNMR和MS进行鉴定。初步测试了它们对金属离子的配位性能，这些多取代氨基硫脲配体很容易与Cu^2^+、Co^2^+、Ni^2^+、Zn^2^+、Ag^+、Hg^2^+、Hg^2^+~2及稀土离子形成稳定的螯合物。

Synthesis and characterization of some multi-substituted thiosemicarbazones as the multi-dental ligands of mtal ions

Allylthiosemicarbazide(1), prepared from allyl isothiocyanate and hydrazine, reacted with butane 2,3 dione,ninhydrin, or glyoxal to give the corresponding bsutane 2,3 dione bis (4 allylthiosemicarbazone) (2), ninhydrin 1,3 bis(4 allylthiosemicarbazone)(5), or glyoxal bis(4 allylthiosemicarbazone)(6), respectively. Butane 2,3 dione bis thiosemicarbazone(3)was obtained via the reaction of butane 2,3 dione and aminothiourea. Cyclohexanone 4 allylthiosemicarbazone(4) was also prepared in a similar way. The complexation behavior of there compounds with some metal ions under different conditions was briefly investigated .