Simultaneous Determination of Ritodrine and Isoxsuprine Using Coupling Technique of Synchronous Fluorimetry and H-Point Standard Addition Method

Simultaneous determination of two structurally related ß₂ adrenergic receptor agonists namely, Ritodrine HCl (RTH) and Isoxsuprine HCl (ISP) was performed using coupling technique of synchronous fluorimetry and H-point standard addition method. Under optimum conditions, linear determination ranges were 1.48 – 14.80?×?10^?6 mol L^?1 and 1.54 – 15.44?×?10^?6 mol L^?1 for ISP and RTH respectively. RTH and ISP could be determined simultaneously without interference from each other when their concentration ratio varies from 5:1 to 1:5 in the mixed sample. The proposed method was applied to the determination of RTH and ISP in synthetic mixture of pharmaceutical samples, the accuracy and precision of the results were satisfactory.