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| 2—甲基乙酰苯胺合成工艺的优化 | |
| 引用本文： | 王雅珍,祁秀春,郭晓振. 2—甲基乙酰苯胺合成工艺的优化[J]. 江苏技术师范学院学报, 2011, 17(8): 24-27 |
| 作者姓名： | 王雅珍 祁秀春 郭晓振 |
| 作者单位： | 1. 江苏技术师范学院化学与环境工程学院,江苏常州,213001 2. 江苏技术师范学院数理学院,江苏常州,213001 3. 无锡科锋化工有限公司,江苏无锡,214194 |
| 摘 要： | 以邻甲苯胺为原料,以冰醋酸为酰化试剂来合成邻甲基乙酰苯胺,考察影响酰化反应的主要因素,结果表明最适宜的反应条件是:锌粉冰醋酸的用量为邻甲苯胺:锌粉=0.1mol:0.1g。n(冰醋酸):n(邻甲苯胺)=5:1;分馏温度控制在100～105℃,最终所得产品收率可达81.5%。 |
| 关 键 词： | 2-甲苯胺 冰醋酸 酰化邻甲基乙酰苯胺 |
Optimization in the Synthesis of 2-Methylacetanilide |
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| WANG Ya-zhen,QI Xiu-chun,GUO Xiao-zhen. Optimization in the Synthesis of 2-Methylacetanilide[J]. Journal of Jiangsu Teachers University of Technology, 2011, 17(8): 24-27 | |
| Authors: | WANG Ya-zhen QI Xiu-chun GUO Xiao-zhen |
| Affiliation: | 1.School of Chemistry and Environmental Engineering,Jiangsu Teachers University of Technology,Changzhou 213001,China;2.School of Mathematics and Physics,Jiangsu Teachers University of Technology,Changzhou 213001,China;3.Wuxi Kefeng Chemical Engineering Co.,Ltd., Wuxi 214194,China) |
| Abstract: | 2-Methylacetanilide was synthesized with O-toluidine as raw material and acetic acid as reagent of acylation.The factors that have influence on the action were investigated.The results showed that the optimal condition were molar ratio of Zinc of dosage with ratio of 2-toluidine to Zn 0.1mol：0.1g,the molar ratio of 2-toluidine to acetic acid 0.2：0.5;acylation 100～105℃,the yield of 2-Methylacetanilide such conditions was about 81.8%. |
| Keywords: | 2-toluidine acetic acid Acylation 2-Methylacetanilide |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |