Systematic fabrication of chitosan nanoparticle by gamma irradiation |
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| Authors: | Wanvimol Pasanphan Pakjira Rimdusit Surakarn Choofong Thananchai Piroonpan Sunchai Nilsuwankosit |
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| Institution: | 1. The Department of Applied Radiation and Isotopes, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand;2. The Department of Nuclear Technology, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand;1. School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan;2. Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan;3. Department of Otolaryngology, Chi Mei Medical Center, Taipei, Taiwan;4. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243, Taiwan;5. Department of Biochemistry and Molecular Cell Biology, School of medicine, College of medicine, Taipei Medical University, Taipei, Taiwan;6. Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan;7. Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan;1. Collaborative Innovation Center for Advanced Nuclear Energy Technology, INET, Tsinghua University, Beijing 100084, PR China;2. Beijing Key Laboratory of Radioactive Waste Treatment, INET, Tsinghua University, Beijing 100084, PR China;1. Department of Food Science and Technology, College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu, 610065, PR China;2. Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, PR China;3. Department of Public Health, Chengdu Medical College, Chengdu, 610500, PR China;4. Sichuan Institute of Atomic Energy, Chengdu, 610101, PR China;5. Department of Animal and Food Sciences, University of Kentucky, Lexington, KY, 40546, USA;1. Center for Graduate Education, Shandong Academy of Medical Sciences, Jinan 250062, China;2. Zhangqiu People''s Hospital, Zhangqiu 250200, China;1. Department of Agricultural Microbiology, Faculty of Agriculture, Ain Shams University, Egypt;2. Department of Radiation Microbiology, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt |
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| Abstract: | The present investigation is mainly focused on the systematic preparation of chitosan nanoparticle in the potential range 1–100 nm using γ-ray irradiation. The effect of irradiation conditions in terms of physical form of chitosan, i.e. flake, colloidal and acidic solution, and γ-ray dose was studied. The molecular weights of chitosan were 10, 25, and >1000 times reduced when irradiated with the γ-ray dose as high as 100 kGy in Chi-flake, Chi-colloid, and Chi-acid, respectively. The particle size reduced to 70 nm after being irradiated to only 10 kGy γ-rays and it showed a tendency to decrease when the γ-ray doses were increased. The γ-rays effectively induced the reduction of chitosan particle size to <100 nm with narrow size distribution. The effective size reduction was particularly observed in Chi-colloid. Heterogeneous chemical conjugation of deoxycholic acid onto 10 kGy irradiated Chi-colloid resulted in narrow particle size as small as 50 nm. |
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