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Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems |
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| Authors: | Jade B Aitken Elizabeth A Carter Harold Eastgate Mark J Hackett Hugh H Harris Aviva Levina Yao-Chang Lee Ching-Iue Chen Barry Lai Stefan Vogt Peter A Lay |
| Institution: | 1. Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan;2. Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;3. Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan;4. Department of Cardiology, Tokyo Medical and Dental University, Tokyo, Japan;1. European Organization for Nuclear Research – CERN, CH-1211 Genève 23, Switzerland;2. Budapest University of Technology and Economics, Faculty of Mechanical Engineering, Department of Materials Science and Engineering, 1111 Budapest, M?egyetem rkp. 3, Hungary |
| Abstract: | Protein crystallography and NMR spectroscopy took decades to emerge as routine techniques in structural biology. X-ray absorption spectroscopy now has reached a similar stage of maturity for obtaining complementary local structural information around metals in metalloproteins. However, the relatively recent emergence of X-ray and vibrational spectroscopic microprobes that build on these techniques has enabled the structural information obtained from the “mature” techniques on isolated biomolecules to be translated into in situ structural information from inhomogeneous complex systems, such as whole cells and tissues. |
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