Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application |
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| Authors: | Simonida Lj Tomić Maja M Mićić Sava N Dobić Jovanka M Filipović Edin H Suljovrujić |
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| Institution: | 1. Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3000, Querétaro, Mexico;2. Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Avenida Instituto Politécnico Nacional 2508, San Pedro Zacatenco, 07360 Ciudad de México, Mexico;3. CONACYT, Departamento de Investigación en Física, Universidad de Sonora, Apdo. Postal 5-88, 83190 Hermosillo, Sonora, Mexico;4. CONACyT, Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3000, Querétaro, Mexico;5. Universidad del Valle de México, Campus Querétaro, Blvd. Juriquilla 3000, Juriquilla, Querétaro, Mexico;1. University of Maribor, Faculty of Natural Sciences and Mathematics, Koro?ka 160, 2000 Maribor, Slovenia;2. University of Maribor, Faculty of Chemistry and Chemical Engineering, PolyOrgLab, Smetanova 17, SI-2000 Maribor, Slovenia;3. National Institute of Chemistry, Department for Polymer Chemistry and Technology, Hajdrihova 19, 1000 Ljubljana, Slovenia |
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| Abstract: | pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by γ-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. |
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