Thermal studies of some biological active oxadiazoles |
| |
Authors: | Sanjiv Arora Deepak K Aneja Mahesh Kumar Chetan Sharma Om Prakash |
| |
Institution: | 1. Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India 2. Department of Microbiology, Kurukshetra University, Kurukshetra, 136119, Haryana, India 3. Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, 136119, Haryana, India
|
| |
Abstract: | A series of new unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles (3a–d) has been synthesized to evaluate their antibacterial and thermal properties. All compounds have been tested for their in vitro antibacterial activity against two Gram-positive bacteria namely, Staphylococcus aureus and Bacillus subtilis. Among the tested compounds, compound 2-(4-chlorophenyl)-5-(thiophen-2-yl)-1,3,4-oxadiazole (3c) has been found to be most potent member having minimum inhibitory concentration. Thermal stability and melting point of compounds have been studied by TG and DSC analysis in air atmosphere at heating rate of 10 °C min?1. Thermal degradation kinetics of the most potent antibacterial compound 3c has been carried out by multiple heating rate model free kinetic methods namely, Ozawa–Flynn–Wall, modified Coats-Redfern, and Kissinger. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|