Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry |
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Authors: | Cai-yun Wang Fen Xu Li-xian Sun Yu-Jia Sun Shu-jun Qiu Zhong-bao Zhao Hai-dong Tan Shuang Wang |
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Institution: | 1. College of Chemistry and Chemical Engineering, Liaoning Normal University, 850 Huanghe Road, Dalian, 116029, People’s Republic of China 2. Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, People’s Republic of China 3. College of Chemistry & Molecular Science, Wuhan University, Wuhan, 430072, People’s Republic of China 4. School of Material Science and Engineering, Guilin University of Electronic Technology, 1 Jinji Road, Guilin, 541004, People’s Republic of China
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Abstract: | A microcalorimetric technique was used to evaluate the influence of both Levofloxacin lactate in sodium chloride injection (drug A) and Levofloxacin hydrochloride in sodium chloride injection (drug B) on the metabolism of Escherichia coli. By means of an isothermal calorimeter and ampoule method at 37 °C, the power-time curves of E. coli growth were obtained under different conditions. The parameters such as the growth rate constant k, maximum power output P m, time t m corresponding to the maximum power output and inhibitory ratio I of these two drugs were obtained. The results reveal that the inhibitory abilities enhance with increasing concentrations of the two drugs. The critical growth concentration and the half-inhibitory concentration IC50 were 0.15 and 0.079 μg mL?1 (for drug A), 0.13 and 0.061 μg mL?1 (for drug B), respectively. These results show the drug A has slightly better inhibitory effect on E. coli than that of drug B. |
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