Overproduction of riboflavin by anArthrobacter sp. mutant resistant to 5-fluorouracil |
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| Authors: | Yoshiharu Yamane Yozo Nakamura Hiroyuki Okamoto Hiroshi Ooshima Jyoji Kato |
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| Affiliation: | (1) Department of Bioapplied Chemistry, Osaka City University, Sugimoto, Sumiyoshi-Ku, 558 Osaka, Japan |
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| Abstract: | Effects of pH and dissolved oxygen concentration on batchwise riboflavin production by a 5-fluorouracil (5-FU)-resistant mutant ofArthrobacter sp. were investigated. The reaction was carried out in a jar fermentor. The optimal pH of culture medium was around 7.3. Dissolved oxygen concentration was almost constant during fermentation at 600 rpm of agitation rate. Production of riboflavin reached a maximum of 160 mg/L after 70 h fermentation under the agitation rate of 600 rpm, aeration rate of 1.0 L/min, and pH 7.0. |
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| Keywords: | Riboflavin Arthrobacter sp. jar fermentor pH dissolved oxygen |
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