Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents |
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| Authors: | Fischer Christian Fu Gregory C |
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| Affiliation: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
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| Abstract: | A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess. |
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