Synthesis, Characterization, and Biological Activity of Amino Acid Derivatives of the Heteropolytungstophosphoric Acid |
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| Authors: | Vesna Kuntić Maja Stanojević Ivanka Holclajtner-Antunović Snežana Uskoković-Marković Ubavka Mioč Marija Todorović Tanja Jovanović Vladana Vukojević |
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| Institution: | (1) Department of Physical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia and Montenegro;(2) Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro;(3) Faculty of Physical Chemistry, University of Belgrade, Belgrade, Serbia and Montenegro;(4) Department of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia and Montenegro;(5) Faculty of Chemistry, University of Belgrade, Belgrade, Serbia and Montenegro;(6) Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden |
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| Abstract: | Summary. Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA–Ala) or glycine (WPA–Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular
toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized
compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2. |
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| Keywords: | , Heteropoly compounds, Amino acids, IR spectroscopy, Cellular toxicity, Antiviral activity, |
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