Effects of the group I metabotropic glutamate receptor agonist,DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats |
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| Authors: | Yan?Pan Yemiliya?Berman Email author" target="_blank">Kenneth?D?CarrEmail author |
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| Institution: | (1) Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA;(2) Department of Pharmacology, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA |
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| Abstract: | Background Chronic food restriction augments the rewarding effect of centrally administered psychostimulant drugs and this effect may
involve a previously documented upregulation of D-1 dopamine receptor-mediated MAP kinase signaling in nucleus accumbens (NAc)
and caudate-putamen (CPu). Psychostimulants are known to induce striatal glutamate release, and group I metabotropic glutamate
receptors (mGluR) have been implicated in the cellular and behavioral responses to amphetamine. The purpose of the present
study was to evaluate whether chronic food restriction increases striatal MAP kinase signaling in response to the group I
mGluR agonist, DHPG. |
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