O2 activation by bis(imino)pyridine iron(II)-thiolate complexes |
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Authors: | Badiei Yosra M Siegler Maxime A Goldberg David P |
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Institution: | Department of Chemistry, Johns Hopkins University , Baltimore, Maryland 21212, United States. |
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Abstract: | The new iron(II)-thiolate complexes ((iPr)BIP)Fe(II)(SPh)(Cl)] (1) and ((iPr)BIP)Fe(II)(SPh)(OTf)] (2) BIP = bis(imino)pyridine] were prepared as models for cysteine dioxygenase (CDO), which converts Cys to Cys-SO(2)H at a (His)(3)Fe(II) center. Reaction of 1 and 2 with O(2) leads to Fe-oxygenation and S-oxygenation, respectively. For 1 + O(2), the spectroscopic and reactivity data, including (18)O isotope studies, are consistent with an assignment of an iron(IV)-oxo complex, ((iPr)BIP)Fe(IV)(O)(Cl)](+) (3), as the product of oxygenation. In contrast, 2 + O(2) results in direct S-oxygenation to give a sulfonato product, PhSO(3)(-). The positioning of the thiolate ligand in 1 versus 2 appears to play a critical role in determining the outcome of O(2) activation. The thiolate ligands in 1 and 2 are essential for O(2) reactivity and exhibit an important influence over the Fe(III)/Fe(II) redox potential. |
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