Fluorescent penta- and hexaene fatty acids by a Wittig-Horner/elimination strategy |
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Authors: | Patalag Lukas J Werz Daniel B |
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Institution: | Institut für Organische und Biomolekulare Chemie, Georg-August-Universit?t G?ttingen, Tammannstr. 2, 37077 G?ttingen, Germany. |
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Abstract: | Molecular fluorescent probes have revolutionized biochemical and biophysical studies in the last decades, but with regard to lipids there has been a lack of combining the slim shape of saturated acyl chains with fluorescent properties. Our strategy to pentaene and hexaene fatty acids builds upon commercially available 4-(E)-decenal, which is subjected to a Wittig-Horner reaction after chlorination in α-position. DBU-mediated β-elimination of HCl proceeding the olefination establishes a highly conjugated system to which a salt-free Wittig reaction adds a final double bond leading to a good (Z)-selectivity of 83-86%. The double bond geometry can be optionally isomerized with I(2) to furnish the all-(E)-species. The five conjugated alkene moieties result in a longest-wavelength absorption maximum of about 350 nm. A red-shift to 380 nm was realized by addition of another double bond employing a common Wittig-Horner prolongation sequence. Stokes shifts of about 7300 and 7800 cm(-1), respectively, were observed. |
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