Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter" |
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| Authors: | Plaza Alberto Garcia Ronald Bifulco Giuseppe Martinez Javier Pablo Hüttel Stephan Sasse Florenz Meyerhans Andreas Stadler Marc Müller Rolf |
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| Affiliation: | Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Universit?t des Saarlandes, Postfach 151150, 66041 Saarbrücken, Germany. |
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| Abstract: | Aetheramides are structurally distinctive cyclic peptides isolated from a novel myxobacterial genus proposed to be termed "Aetherobacter". The structures were solved by a combination of NMR analyses, quantum mechanical calculations, and chemical derivatizations. Aetheramides which contain a unique polyketide moiety and two amino acid residues potently inhibited HIV-1 infection with IC(50) values of ~0.015 μM. Furthermore aetheramides showed cytostatic activity against human colon carcinoma (HCT-116) cells with IC(50) values of 0.11 μM. |
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