Flavusides A and B, antibacterial cerebrosides from the marine-derived fungus Aspergillus flavus |
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Authors: | Yang Guohua Sandjo Louis Yun Keumja Leutou Alain Simplice Kim Gun-Do Choi Hong Dae Kang Jung Sook Hong Jongki Son Byeng Wha |
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Institution: | Department of Chemistry, Pukyong National University, Busan 608-737, Korea. |
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Abstract: | Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 μg/ml for S. aureus and 31.2 μg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 μg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 μg/ml for multidrug-resistant S. aureus. |
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