| Studies on Antivirus Effects of Polysaccharides from Sargassum fusiforme in vitro |
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| 引用本文： | CEN,Ying-Zhou KHOO,Gaik-Ming WANG,Ling-Yun ZHANG,Ying. Studies on Antivirus Effects of Polysaccharides from Sargassum fusiforme in vitro[J]. 有机化学, 2004, 24(Z1): 128-129 |
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| 作者姓名： | CEN Ying-Zhou KHOO Gaik-Ming WANG Ling-Yun ZHANG Ying |
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| 作者单位： | CEN,Ying-Zhou（Department of Chemistry, Jinan University, Guangzhou 510632） KHOO,Gaik-Ming（Department of Chemistry, Jinan University, Guangzhou 510632） WANG,Ling-Yun（Department of Chemistry, Jinan University, Guangzhou 510632） ZHANG,Ying（Department of Chemistry, Jinan University, Guangzhou 510632） |
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| 基金项目： | 国家自然科学基金，国家自然科学基金 |
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| 摘 要： | To assay antiviral effects of the polysaccharide and its separated products from Sargassumfusiforme on HSV-1 and CVB3 and their antiviral mechanism, the antiviral effects of all samples on HSV-1 and CVB3 and their cytotoxicity on vero cells were studied by CPE and MTT method. Antiviral mechanism of two samples was briefly studied by four different ways. The cytotoxicity of samples on vero cells was not detected (CC＞5000 μg/mL). All samples except PSJ had obviously HSV-1 inhibitory effect. Antiviral activities of them were increasingly strengthened with raising their purities.Antiviral activities of F1, F2 and F4 were better than that of ACV, and antiviral activities of all samples on CVB3 were better than ribavirin injection. Fi, F2 and F4 had remarkable anti-CVB3 activity. The experiment showed that polysaccharide was able to not only kill the above viruses directly but also restrain them by getting into cell or absorbing on cells.
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Studies on Antivirus Effects of Polysaccharides from Sargassum fusiforme in vitro |
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| CEN,Ying-Zhou,KHOO,Gaik-Ming,WANG,Ling-Yun,Zhang Ying. Studies on Antivirus Effects of Polysaccharides from Sargassum fusiforme in vitro[J]. Chinese Journal of Organic Chemistry, 2004, 24(Z1): 128-129 |
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| Authors: | CEN Ying-Zhou KHOO Gaik-Ming WANG Ling-Yun Zhang Ying |
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| Abstract: | To assay antiviral effects of the polysaccharide and its separated products from Sargassumfusiforme on HSV-1 and CVB3 and their antiviral mechanism, the antiviral effects of all samples on HSV-1 and CVB3 and their cytotoxicity on vero cells were studied by CPE and MTT method. Antiviral mechanism of two samples was briefly studied by four different ways. The cytotoxicity of samples on vero cells was not detected (CC＞5000 μg/mL). All samples except PSJ had obviously HSV-1 inhibitory effect. Antiviral activities of them were increasingly strengthened with raising their purities.Antiviral activities of F1, F2 and F4 were better than that of ACV, and antiviral activities of all samples on CVB3 were better than ribavirin injection. Fi, F2 and F4 had remarkable anti-CVB3 activity. The experiment showed that polysaccharide was able to not only kill the above viruses directly but also restrain them by getting into cell or absorbing on cells. |
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