Preparation of <span class="math"><math><mtext>gem</mtext></math></span>-difluorocyclopropanes <span class="math"><math><mtext>via</mtext></math></span> decomposition of methyl chlorodifluoroacetate by alkali metal halides期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Preparation of $gem$ -difluorocyclopropanes $via$ decomposition of methyl chlorodifluoroacetate by alkali metal halides

Authors:	GA Wheaton DJ Burton

Institution:	Department of Chemistry, University of Iowa, Iowa City, Iowa 52242 U.S.A.

Abstract:	The facile decomposition of methyl chlorodifluoroacetate, induced by either lithium chloride/hexamethylphosphoric triamide complex or potassium fluoride/18-Crown-6 complex, has been carried out in the presence of a variety of olefinic substrates to yield the corresponding $gem$ -difluorocyclopropanes. The ester decomposition has been determined to yield “free” difluorocarbene $via$ a three-step process involving an intermediate chlorodifluoromethide ion.

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