| Differential Expressing of Centromere Protein CenpG in Breast Cancer |
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| 作者姓名： | 梁前进 Lu Xiangfeng Cheng Xiaolei Zhang Huanxiang He Dacheng WANG Yongchao |
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| 作者单位： | [1]CollegeofLifeSciences,BeijingNormaluniversity,Beijing100875,P.R.China [2]DongzhimenHospitalofBeijingUniversityofChineseTraditionalMedicine,Beijing100700,P.R.China |
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| 基金项目： | supported by the funds of State Major Basic Research Development Project (“97.3 Project) of China，国家自然科学基金 |
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| 摘 要： | Using indirect immunofluorescence (IIF),an anti-centromere protein CenpG-serum was verified.Western blot of the protein extracts of 31 samples of breast cancer tissues and their normal (not cancerous) tissues a little far away from them in the same individuals showed that,in the majority of the tests(71%),centromere protein CenpG over expressed in breast cancer tissues,And moreover,a kind of protein component whose molecular weight is 43 kd,and which can be recognized by anti-CenpG serum sas found in two of the caner samples,The results suggested that CenpG (together whith it,there may be other relative components),which has been foud and named recently,may be related to cancer,and its differential expressing is probably related to malignant cell proliferation.
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| 关 键 词： | 乳癌 蛋白质 CenpG 不同表现 |
Differential Expressing of Centromere Protein CenpG in Breast Cancer |
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| Lu Xiangfeng,Cheng Xiaolei,Zhang Huanxiang,He Dacheng,WANG Yongchao.Differential Expressing of Centromere Protein CenpG in Breast Cancer[J].High Technology Letters,2002,8(1):1-4. |
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| Authors: | Lu Xiangfeng Cheng Xiaolei Zhang Huanxiang He Dacheng WANG Yongchao |
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| Abstract: | Using indirect immunofluorescence (IIF), an anti-centromere protein CenpG-serum was verified. Western blot of the protein extracts of 31 samples of breast cancer tissues and their normal (not cancerous ) tissues a little far away from them in the same individuals showed that, in the majority of the tests (71%), centromere protein CenpG over expressed in breast cancer tissues. And moreover, a kind of protein component whose molecular weight is 43 kd, and which can be recognized by anti-CenpG serum was found in two of the cancer samples. The results suggested that CenpG (together whith it, there may be other relative components),which has been found and named recently, may be related to cancer,and its differential expressing is probably related to malignant cell proliferation. |
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| Keywords: | Breast cancer Centromere protein Cenp |
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