| Synthesis and Cleavage Activity of Artifical Minic Polypeptides |
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| 引用本文： | Yong YE Xiao Lian HU Ping LI Ming Yu NIU Li Feng CAO Yu Fen ZHAO. Synthesis and Cleavage Activity of Artifical Minic Polypeptides[J]. 中国化学快报, 2006, 17(9): 1197-1200 |
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| 作者姓名： | Yong YE Xiao Lian HU Ping LI Ming Yu NIU Li Feng CAO Yu Fen ZHAO |
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| 作者单位： | [1]Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450052 [2]Key laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education）, Department of Chemistry, Tsinghua University, Beijing 100084 |
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| 摘 要： | Natural product distamycin and netropsin are polyamide containing three N-methyl- pyrrole (Py) moieties. They have ability to binding to the minor groove of A·T-rich sequences of double–helical DNA. Thus, much attention has been attracted to the synthes…
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| 关 键 词： | DNA 分裂活性 人造微多肽 结构分析 |
| 收稿时间： | 2006-03-29 |
Synthesis and Cleavage Activity of Artifical Minic Polypeptides |
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| Yong YE,Xiao Lian HU,Ping LI,Ming Yu NIU,Li Feng CAO,Yu Fen ZHAO. Synthesis and Cleavage Activity of Artifical Minic Polypeptides[J]. Chinese Chemical Letters, 2006, 17(9): 1197-1200 |
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| Authors: | Yong YE Xiao Lian HU Ping LI Ming Yu NIU Li Feng CAO Yu Fen ZHAO |
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| Affiliation: | Ministry of Education |
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| Abstract: | Two artificial minic polypeptides which are synthetic analogues of natural products with DNA affinity were synthesized, and theirs cleavage activity with DNA were examined. The structures of these compounds was confirmed by 1H NMR, MS and IR. |
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| Keywords: | DNA artificial minic polypeptide cleavage agents. |
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