The state of the art in thin-layer chromatography-mass spectrometry: a critical appraisal. |
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| Authors: | I D Wilson |
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| Affiliation: | Department of Safety of Medicines, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK. |
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| Abstract: | Thin-layer chromatography-mass spectrometry (TLC-MS) is a readily implemented technique that, in its simplest form, puts few demands on either chromatography or spectrometry. Nevertheless, compared to the situation with high performance liquid chromatography, it is much less highly developed. Currently, the bulk of the practical applications of TLC-MS are directed towards the use of fast atom, or ion bombardment. Recent developments, however, include the use of matrix assisted laser desorption ionisation (MALDI), surface assisted laser desorption (SALDI) and the development of a TLC-electrospray interface. Here, the state of the art of TLC-MS is described and future trends identified. |
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