A domino ring-opening/epoxidation of 1,2-dioxines |
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| Authors: | Greatrex Ben W Taylor Dennis K Tiekink Edward R T |
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| Affiliation: | Department of Chemistry, University of Adelaide, South Australia 5005, Australia. |
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| Abstract: | When allowed to react with alkaline hydrogen peroxide, monocyclic 1,2-dioxines ring-open to their isomeric gamma-hydroxyenone intermediates which are rapidly epoxidized to afford trans-4-hydroxy-2,3-epoxyketones in 21-81% yield. In the case of meso-1,2-dioxines, Co(II) complex catalyzed asymmetric ring-opening of the 1,2-dioxine may be employed to furnish enantioenriched epoxides |
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